Valves for analytical High Performance Liquid Chromatography (HPLC) can be actuated manually or automated with pneumatic or electric actuators. There are a number of different valves and actuators:
Switching Valves are compact, motorized standalone modules that are ready-to-use alternatives to manual selection valves. Each module has a unique flow switching pattern that is designed for a certain set of laboratory tasks. These switching valves can automate things like solvent selection, column selection, sample selection, column cleaning/conditioning, and alternating column regeneration.
Injection Valves are a means to inject a sample of a certain volume into the mobile phase. The injection loop is a critical component of the injection valve and a critical part of an HPLC because it dictates the sample volume.
The injection loop is a critical component of an HPLC and is potentially one of the largest sources of excess HPLC system volume. The sample is injected into the loop while the loop is switched out of the HPLC flow path. After the loop is filled with sample it is switched back into the flow path and the sample is swept onto the head of the HPLC column for later elution or the sample is injected directly into a mass spectrometer as part of a flow injection analysis.
Top HPLC Valve Manufacturers
Popular manufacturers are Rheodyne, Valco Instruments Company Inc. (VICI), Gilson, Waters Corporation, and Agilent Technologies Inc.
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