Millipore Tangential Flow Filtration (TFF) Skid Systems

The Millipore Tangential Flow Filtration (TFF) Skid Systems are state-of-the-art, automated platforms engineered to deliver precise and reproducible separation of biomolecules in biopharmaceutical manufacturing. Whether used for pilot-scale development or large-scale production, these systems provide unmatched efficiency in processing monoclonal antibodies, vaccines, plasma, and therapeutic proteins. Built to meet the demanding standards of modern bioprocessing, Millipore TFF skids are trusted worldwide for their scalability, consistency, and compliance with cGMP environments.

At HiTechTrader, we make this high-level technology accessible by offering carefully refurbished and pre-owned Millipore TFF Skid Systems. Every unit undergoes rigorous inspection, performance validation, and safety checks to ensure dependable operation. This allows your lab or production facility to leverage world-class filtration systems at a fraction of the cost, enabling you to scale processes confidently without compromising reliability or quality.

Key Features

Vessel & Construction

1. Stainless steel design compatible with cGMP environments.
2. Integrated NovAseptic® valves and cassette holders to minimize dead volume.
3. Supports Pellicon® 2 and Pellicon® 3 cassettes for flexibility.
4. Low hold-up volume design maximizes product recovery.
5. Compact skid footprint for seamless installation and integration.

Closure & Sealing

1. Vessel pressure range: -1 to +3 bar; skid supports up to +5 bar.
2. Operates safely across +5 °C to +80 °C.
3. Integrated integrity test ports for process validation.
4. Equipped with pressure transmitters for safe and reliable operation.

Operating Parameters

1. Size A: Flow rates up to 50 L/min (~5 m² filtration area).
2. Size B: Flow rates up to 120 L/min (~20 m² filtration area).
3. Size C: Flow rates up to 240 L/min (~40 m² filtration area).
4. Modes supported: fed-batch, concentration, total recycle, and single-pass.
5. PLC-driven automation for precise control.
6. Endress+Hauser MASS flow meters and conductivity sensors with ±1–2% accuracy.

Accessory Compatibility

1. Optional supply vessels: 50 L, 200 L, or 500 L.
2. Works with fed-batch and continuous processing setups.
3. Interfaces seamlessly with MES systems for automation.
4. Multiple cassette formats for scalable bioprocessing.
5. Designed for CIP/SIP cleanroom integration.

Safe Operation Guidelines

1. Confirm utilities and compressed air meet specifications before use.
2. Maintain proper operating pressures and vessel limits.
3. Calibrate sensors routinely to ensure compliance and accuracy.
4. Verify cassette installation before starting a batch.
5. Follow cGMP cleaning and sterilization protocols.

Applications

1. Concentration and diafiltration of therapeutic proteins.
2. Purification of monoclonal antibodies.
3. Vaccine and plasma fractionation.
4. Aggregate removal and clarification.
5. Bioprocessing in food, beverage, and biotechnology.
6. Industrial water and process fluid purification.

Why Buy from HiTechTrader?

For more than 30 years, HiTechTrader has helped biopharmaceutical and industrial facilities access top-tier equipment at significantly reduced costs. Every Millipore TFF Skid System we offer is meticulously tested for quality, safety, and precision, ensuring you can integrate it into critical processes with confidence. By partnering with HiTechTrader, you gain not only cost savings but also expert support and long-term reliability, so your operations stay efficient, compliant, and future-ready.